IF you have VirtualPC for your Mac, then you should be able to play at Ultimate Bet, which is a rocking good poker room. I've heard that Party Poker MIGHT work on a Macintosh computer, but that it was buggy and unreliable, so I don't recommend it.
If you don't have VirtualPC and don't want to get it, as was the case with my correspondent today, my recommendation is Poker Room. You want to use the "light" version, which runs on java right there in your browser and couldn't be easier. So if you're a Mac user, and you want to get in on the online poker craze, Poker Room is your solution.